The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties.

We demonstrate here that the human oestrogen receptor (hER) cDNA clone pOR8 obtained from MCF-7 cells contains an artefactual point mutation which results in the substitution of a valine for a glycine at amino acid position 400 (Gly-400----Val-400). This mutation in the hormone binding domain of the...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Tora, L, Mullick, A, Metzger, D, Ponglikitmongkol, M, Park, I, Chambon, P
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 1989
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC401066/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2792078/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1989.tb03604.x
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