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The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties.

We demonstrate here that the human oestrogen receptor (hER) cDNA clone pOR8 obtained from MCF-7 cells contains an artefactual point mutation which results in the substitution of a valine for a glycine at amino acid position 400 (Gly-400----Val-400). This mutation in the hormone binding domain of the...

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Udgivet i:EMBO J
Principais autores: Tora, L, Mullick, A, Metzger, D, Ponglikitmongkol, M, Park, I, Chambon, P
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC401066/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2792078/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1989.tb03604.x
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