Mitochondrial DAMPs Induce Endotoxin Tolerance in Human Monocytes: An Observation in Patients with Myocardial Infarction

Monocyte exposure to mitochondrial Danger Associated Molecular Patterns (DAMPs), including mitochondrial DNA (mtDNA), induces a transient state in which these cells are refractory to further endotoxin stimulation. In this context, IRAK-M up-regulation and impaired p65 activity were observed. This ph...

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Main Authors: Fernández-Ruiz, Irene, Arnalich, Francisco, Cubillos-Zapata, Carolina, Hernández-Jiménez, Enrique, Moreno-González, Raúl, Toledano, Víctor, Fernández-Velasco, María, Vallejo-Cremades, Maria T., Esteban-Burgos, Laura, de Diego, Rebeca Pérez, Llamas-Matias, Miguel A., García-Arumi, Elena, Martí, Ramón, Boscá, Lisardo, Andreu, Antoni L., López-Sendón, José Luis, López-Collazo, Eduardo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010397/
https://ncbi.nlm.nih.gov/pubmed/24797663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095073
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