Direct Evidence for Pitavastatin Induced Chromatin Structure Change in the KLF4 Gene in Endothelial Cells

Statins exert atheroprotective effects through the induction of specific transcriptional factors in multiple organs. In endothelial cells, statin-dependent atheroprotective gene up-regulation is mediated by Kruppel-like factor (KLF) family transcription factors. To dissect the mechanism of gene regu...

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Detalhes bibliográficos
Main Authors: Maejima, Takashi, Inoue, Tsuyoshi, Kanki, Yasuharu, Kohro, Takahide, Li, Guoliang, Ohta, Yoshihiro, Kimura, Hiroshi, Kobayashi, Mika, Taguchi, Akashi, Tsutsumi, Shuichi, Iwanari, Hiroko, Yamamoto, Shogo, Aruga, Hirofumi, Dong, Shoulian, Stevens, Junko F., Poh, Huay Mei, Yamamoto, Kazuki, Kawamura, Takeshi, Mimura, Imari, Suehiro, Jun-ichi, Sugiyama, Akira, Kaneki, Kiyomi, Shibata, Haruki, Yoshinaka, Yasunobu, Doi, Takeshi, Asanuma, Akimune, Tanabe, Sohei, Tanaka, Toshiya, Minami, Takashi, Hamakubo, Takao, Sakai, Juro, Nozaki, Naohito, Aburatani, Hiroyuki, Nangaku, Masaomi, Ruan, Xiaoan, Tanabe, Hideyuki, Ruan, Yijun, Ihara, Sigeo, Endo, Akira, Kodama, Tatsuhiko, Wada, Youichiro
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010393/
https://ncbi.nlm.nih.gov/pubmed/24797675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096005
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