Enhancement of cellular uptake and cytotoxicity of curcumin-loaded PLGA nanoparticles by conjugation with anti-P-glycoprotein in drug resistance cancer cells

AIM: To compare the anti-cancer activity and cellular uptake of curcumin (Cur) delivered by targeted and non-targeted drug delivery systems in multidrug-resistant cervical cancer cells. METHODS: Cur was entrapped into poly (DL-lactide-co-glycolide) (PLGA) nanoparticles (Cur-NPs) in the presence of m...

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Autors principals: Punfa, Wanisa, Yodkeeree, Supachai, Pitchakarn, Pornsiri, Ampasavate, Chadarat, Limtrakul, Pornngarm
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010380/
https://ncbi.nlm.nih.gov/pubmed/22580738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.34
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