Preclinical assessment of the distribution, metabolism, and excretion of S-propargyl-cysteine, a novel H(2)S donor, in Sprague-Dawley rats

AIM: To study the distribution, metabolism and excretion of S-propargyl-cysteine (SPRC), a novel hydrogen sulfide (H2S) donor, after oral administration in rats. METHODS: Adult Sprague-Dawley rats were used. The tissue distribution of [(35)S] SPRC-derived radioactivity was measured using a liquid sc...

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Autores principales: Zheng, Yuan-ting, Zhu, Jian-hua, Ma, Guo, Zhu, Qing, Yang, Ping, Tan, Bo, Zhang, Jin-lian, Shen, Hai-xing, Xu, Jia-lin, Zhu, Yi-zhun, Cai, Wei-min
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010370/
https://ncbi.nlm.nih.gov/pubmed/22543704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.15
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