Use of a sensitive and robust UPLC-MS/MS method to determine the gender-dependent pharmacokinetics in rats of emodin and its glucuronide

The purpose of this research was to set up a sensitive and consistent UPLC-UV and UPLCMS/MS method to analyze emodin and its glucuronidated metabolite, and to determine how gender differences affect its pharmacokinetic behaviors. In addition, a breast cancer resistance protein inhibitor dipyridamole...

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Main Authors: Liu, Wei, Gao, Song, Zheng, Zhijie, Liu, Xi, Ye, Ling, Yang, Zhen, Hu, Ming, Liu, Zhongqiu
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010304/
https://ncbi.nlm.nih.gov/pubmed/21195574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2010.12.004
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