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AVE8134, a novel potent PPARα agonist, improves lipid profile and glucose metabolism in dyslipidemic mice and type 2 diabetic rats

AIM: AVE8134 is a structurally novel potent PPARα agonist. The aim of this study is to investigate the efficacy of AVE8134 on lipid profile and glucose metabolism in dyslipidemic mice and type 2 diabetic rats. METHODS: A cell based PPAR Gal4 transactivation assay was constructed for testing the acti...

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Detalhes bibliográficos
Main Authors: Schäfer, Hans Ludwig, Linz, Wolfgang, Falk, Eugen, Glien, Maike, Glombik, Heiner, Korn, Marcus, Wendler, Wolfgang, Herling, Andreas W, Rütten, Hartmut
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010268/
https://ncbi.nlm.nih.gov/pubmed/22212431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.165
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