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Modelling Acidosis and the Cell Cycle in Multicellular Tumour Spheroids

A partial differential equation model is developed to understand the effect that nutrient and acidosis have on the distribution of proliferating and quiescent cells within a multicellular tumour spheroid. The rates of cell quiescence and necrosis are assumed to depend upon the local nutrient and aci...

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Détails bibliographiques
Auteurs principaux: Tindall, M.J., Dyson, L., Smallbone, K., Maini, P.K.
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010153/
https://ncbi.nlm.nih.gov/pubmed/22155133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtbi.2011.11.009
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