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Focused ultrasound for targeted delivery of siRNA and efficient knockdown of Htt expression
RNA interference is a promising strategy for treatment of Huntington’s disease (HD) as it can specifically decrease the expression of the mutant Huntingtin protein (Htt). However, siRNA does not cross the blood-brain barrier and therefore delivery to the brain is limited to direct CNS delivery. Non-...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4010143/ https://ncbi.nlm.nih.gov/pubmed/22921802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2012.08.012 |
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