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NOTCH signaling is required for colon cancer initiating cell tumor formation, self-renewal and repression of secretory cell lineage differentiation
NOTCH signaling fulfills critical functions in intestinal epithelial cell lineage specification and the initiation of colorectal adenomas and colorectal cancers (CRCs). Because NOTCH signaling also plays important roles in the maintenance and self-renewal of cancer initiating cells in several types...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4010106/ https://ncbi.nlm.nih.gov/pubmed/20145124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2557 |
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