Crystal structure of vaccinia virus mRNA capping enzyme provides insights into the mechanism and evolution of the capping apparatus

Vaccinia virus capping enzyme is a heterodimer of D1 (844-aa) and D12 (287-aa) polypeptides that executes all three steps in m(7)GpppRNA synthesis. The D1 subunit comprises an N-terminal RNA triphosphatase (TPase)–guanylyltransferase (GTase) module and a C-terminal guanine-N7-methyltransferase (MTas...

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Bibliographic Details
Main Authors: Kyrieleis, Otto J.P., Chang, Jonathan, de la Peña, Marcos, Shuman, Stewart, Cusack, Stephen
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010090/
https://ncbi.nlm.nih.gov/pubmed/24607143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.12.014
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