Pharmacological mechanisms underlying the antinociceptive and tolerance effects of the 6,14-bridged oripavine compound 030418

AIM: To investigate possible pharmacological mechanisms underlying the antinociceptive effect of and tolerance to N-methyl-7α-[(R)-1-hydroxy-1-methyl-3-(thien-3-yl)-propyl]-6,14-endo-ethanotetrahydronororipavine (030418), a derivative of thienorphine. METHODS: The binding affinity and efficacy of 03...

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Autores principales: Wen, Quan, Yu, Gang, Li, Yu-lei, Yan, Ling-di, Gong, Ze-hui
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2011
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010084/
https://ncbi.nlm.nih.gov/pubmed/21863064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.83
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