PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer

Impairment of double-stranded DNA break (DSB) repair is essential to many cancers. However, while mutations in DSB repair proteins are common in hereditary cancers, mechanisms of impaired DSB repair in sporadic cancers remain incompletely understood. Here, we describe the first role for a long nonco...

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Bibliographische Detailangaben
Hauptverfasser: Prensner, John R., Chen, Wei, Iyer, Matthew K., Cao, Qi, Ma, Teng, Han, Sumin, Sahu, Anirban, Malik, Rohit, Wilder-Romans, Kari, Navone, Nora, Logothetis, Christopher J., Araujo, John C., Pisters, Louis L., Tewari, Ashutosh K., Canman, Christine E., Knudsen, Karen E., Kitabayashi, Naoki, Rubin, Mark A., Demichelis, Francesca, Lawrence, Theodore S., Chinnaiyan, Arul M., Feng, Felix Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4009928/
https://ncbi.nlm.nih.gov/pubmed/24473064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3159
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