PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer

Impairment of double-stranded DNA break (DSB) repair is essential to many cancers. However, while mutations in DSB repair proteins are common in hereditary cancers, mechanisms of impaired DSB repair in sporadic cancers remain incompletely understood. Here, we describe the first role for a long nonco...

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Autors principals: Prensner, John R., Chen, Wei, Iyer, Matthew K., Cao, Qi, Ma, Teng, Han, Sumin, Sahu, Anirban, Malik, Rohit, Wilder-Romans, Kari, Navone, Nora, Logothetis, Christopher J., Araujo, John C., Pisters, Louis L., Tewari, Ashutosh K., Canman, Christine E., Knudsen, Karen E., Kitabayashi, Naoki, Rubin, Mark A., Demichelis, Francesca, Lawrence, Theodore S., Chinnaiyan, Arul M., Feng, Felix Y.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4009928/
https://ncbi.nlm.nih.gov/pubmed/24473064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3159
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