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Global Conformational Dynamics of HIV-1 Reverse Transcriptase Bound to Non-Nucleoside Inhibitors

HIV-1 Reverse Transcriptase (RT) is a multifunctional enzyme responsible for the transcription of the RNA genome of the HIV virus into DNA suitable for incorporation within the DNA of human host cells. Its crucial role in the viral life cycle has made it one of the major targets for antiretroviral d...

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Hlavní autoři: Wright, David W., Hall, Benjamin A., Kellam, Paul, Coveney, Peter V.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4009785/
https://ncbi.nlm.nih.gov/pubmed/24832224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biology1020222
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