Miniaturized Bioaffinity Assessment Coupled to Mass Spectrometry for Guided Purification of Bioactives from Toad and Cone Snail

A nano-flow high-resolution screening platform, featuring a parallel chip-based microfluidic bioassay and mass spectrometry coupled to nano-liquid chromatography, was applied to screen animal venoms for nicotinic acetylcholine receptor like (nAChR) affinity by using the acetylcholine binding protein...

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Hauptverfasser: Heus, Ferry, Otvos, Reka A., Aspers, Ruud L. E. G., van Elk, Rene, Halff, Jenny I., Ehlers, Andreas W., Dutertre, Sébastien, Lewis, Richard J., Wijmenga, Sybren, Smit, August B., Niessen, Wilfried M. A., Kool, Jeroen
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4009767/
https://ncbi.nlm.nih.gov/pubmed/24833338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biology3010139
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