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Developments in sclerostin biology: regulation of gene expression, mechanisms of action, and physiological functions
The SOST gene, which encodes the protein sclerostin, was identified through genetic linkage analysis of sclerosteosis and van Buchem’s disease (VBD) patients. Sclerostin is a secreted glycoprotein that binds to the Low-density lipoprotein Receptor-related Proteins (LRP) 4, 5, and 6 to inhibit Wnt si...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4009626/ https://ncbi.nlm.nih.gov/pubmed/24477413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11914-014-0188-1 |
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