Recurrent epimutations activate gene body promoters in primary glioblastoma

Aberrant DNA hypomethylation may play an important role in the growth rate of glioblastoma (GBM), but the functional impact on transcription remains poorly understood. We assayed the GBM methylome with MeDIP-seq and MRE-seq, adjusting for copy number differences, in a small set of non-glioma CpG isl...

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Detalhes bibliográficos
Main Authors: Nagarajan, Raman P., Zhang, Bo, Bell, Robert J.A., Johnson, Brett E., Olshen, Adam B., Sundaram, Vasavi, Li, Daofeng, Graham, Ashley E., Diaz, Aaron, Fouse, Shaun D., Smirnov, Ivan, Song, Jun, Paris, Pamela L., Wang, Ting, Costello, Joseph F.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4009606/
https://ncbi.nlm.nih.gov/pubmed/24709822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.164707.113
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