Polyinosinic-Polycytidylic Acid Has Therapeutic Effects against Cerebral Ischemia/Reperfusion Injury through the Downregulation of TLR4 Signaling via TLR3

Recent reports have shown that preconditioning with the TLR3 ligand polyinosinic-polycytidylic acid (poly(I:C)) protects against cerebral ischemia/reperfusion (I/R) injury. However, it is unclear whether poly(I:C) treatment after cerebral I/R injury is also effective. We used mouse/rat middle cerebr...

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Detalhes bibliográficos
Main Authors: Wang, Peng-Fei, Fang, Huang, Chen, Jing, Lin, Sen, Liu, Yong, Xiong, Xiao-Yi, Wang, Yan-Chun, Xiong, Ren-Ping, lv, Feng-Lin, Wang, Jian, Yang, Qing-Wu
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2014
Assuntos:
Innate Immunity and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4009499/
https://ncbi.nlm.nih.gov/pubmed/24729619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303108
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