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IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression.

We have generated transgenic mouse lines that carry one of three different constructs in which the murine N-myc gene is expressed under the control of the immunoglobulin heavy chain transcriptional enhancer element (E mu-N-myc genes). High-level expression of the E mu-N-myc transgenes occurred in ly...

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Autors principals: Dildrop, R, Ma, A, Zimmerman, K, Hsu, E, Tesfaye, A, DePinho, R, Alt, F W
Format: Artigo
Idioma:Inglês
Publicat: 1989
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC400923/
https://ncbi.nlm.nih.gov/pubmed/2501083
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