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Use of Bru-Seq and BruChase-Seq for genome-wide assessment of the synthesis and stability of RNA

Gene expression studies commonly examine total cellular RNA, which only provides information about its steady-state pool of RNA. It remains unclear whether differences in the steady-state reflects variable rates of transcription or RNA degradation. To specifically monitor RNA synthesis and degradati...

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Detalhes bibliográficos
Main Authors: Paulsen, Michelle T., Veloso, Artur, Prasad, Jayendra, Bedi, Karan, Ljungman, Emily A., Magnuson, Brian, Wilson, Thomas E., Ljungman, Mats
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4009065/
https://ncbi.nlm.nih.gov/pubmed/23973811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2013.08.015
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