Genome-wide transcriptional effects of the anti-cancer agent camptothecin.

The anti-cancer drug camptothecin inhibits replication and transcription by trapping DNA topoisomerase I (Top1) covalently to DNA in a "cleavable complex". To examine the effects of camptothecin on RNA synthesis genome-wide we used Bru-Seq and show that camptothecin treatment primarily aff...

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Hlavní autoři: Artur Veloso, Benjamin Biewen, Michelle T Paulsen, Nathan Berg, Leonardo Carmo de Andrade Lima, Jayendra Prasad, Karan Bedi, Brian Magnuson, Thomas E Wilson, Mats Ljungman
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2013-01-01
Edice:PLoS ONE
On-line přístup:http://europepmc.org/articles/PMC3806802?pdf=render
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