Imaging the Lipid-Phase-Dependent Pore Formation of Equinatoxin II in Droplet Interface Bilayers

Using phase-separated droplet interface bilayers, we observe membrane binding and pore formation of a eukaryotic cytolysin, Equinatoxin II (EqtII). EqtII activity is known to depend on the presence of sphingomyelin in the target membrane and is enhanced by lipid phase separation. By imaging the ioni...

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Detalles Bibliográficos
Main Authors: Rojko, N., Cronin, B., Danial, J.S.H., Baker, M.A.B., Anderluh, G., Wallace, M.I.
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2014
Assuntos:
Membranes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4008837/
https://ncbi.nlm.nih.gov/pubmed/24739162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.11.4507
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