Observation of Small Cluster Formation in Concentrated Monoclonal Antibody Solutions and Its Implications to Solution Viscosity

Monoclonal antibodies (mAbs) are a major class of biopharmaceuticals. It is hypothesized that some concentrated mAb solutions exhibit formation of a solution phase consisting of reversibly self-associated aggregates (or reversible clusters), which is speculated to be responsible for their distinct s...

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Detalhes bibliográficos
Main Authors: Yearley, Eric J., Godfrin, Paul D., Perevozchikova, Tatiana, Zhang, Hailiang, Falus, Peter, Porcar, Lionel, Nagao, Michihiro, Curtis, Joseph E., Gawande, Pradad, Taing, Rosalynn, Zarraga, Isidro E., Wagner, Norman J., Liu, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2014
Assuntos:
Proteins and Nucleic Acids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4008822/
https://ncbi.nlm.nih.gov/pubmed/24739175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.02.036
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