Small-Angle Neutron Scattering Characterization of Monoclonal Antibody Conformations and Interactions at High Concentrations

Small-angle neutron scattering (SANS) is used to probe the solution structure of two protein therapeutics (monoclonal antibodies 1 and 2 (MAb1 and MAb2)) and their protein-protein interaction (PPI) at high concentrations. These MAbs differ by small sequence alterations in the complementarity-determi...

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Detalhes bibliográficos
Main Authors: Yearley, Eric J., Zarraga, Isidro E., Shire, Steven J., Scherer, Thomas M., Gokarn, Yatin, Wagner, Norman J., Liu, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2013
Assuntos:
Proteins and Nucleic Acids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736689/
https://ncbi.nlm.nih.gov/pubmed/23931320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.06.043
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