Karyopherin-Centric Control of Nuclear Pores Based on Molecular Occupancy and Kinetic Analysis of Multivalent Binding with FG Nucleoporins

Intrinsically disordered Phe-Gly nucleoporins (FG Nups) within nuclear pore complexes exert multivalent interactions with transport receptors (Karyopherins (Kaps)) that orchestrate nucleocytoplasmic transport. Current FG-centric views reason that selective Kap translocation is promoted by alteration...

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Detalhes bibliográficos
Main Authors: Kapinos, Larisa E., Schoch, Rafael L., Wagner, Raphael S., Schleicher, Kai D., Lim, Roderick Y.H.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2014
Assuntos:
Proteins and Nucleic Acids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4008817/
https://ncbi.nlm.nih.gov/pubmed/24739174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.02.021
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