The 5' flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein.

Expression of the pS2 gene which is transcriptionally controlled by oestrogens in the breast cancer cell line MCF-7 is oestrogen independent in stomach mucosa. We show here that the level of MCF-7 cell pS2 mRNA can also be increased by the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA)....

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Sonraí Bibleagrafaíochta
Main Authors: Nunez, A M, Berry, M, Imler, J L, Chambon, P
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1989
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC400880/
https://ncbi.nlm.nih.gov/pubmed/2498085
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