Fatty Acid Amide Hydrolase (FAAH) Inhibitors Exert Pharmacological Effects, but Lack Antinociceptive Efficacy in Rats with Neuropathic Spinal Cord Injury Pain

Amelioration of neuropathic spinal cord injury (SCI) pain is a clinical challenge. Increasing the endocannabinoid anandamide and other fatty acid amides (FAA) by blocking fatty acid amide hydrolase (FAAH) has been shown to be antinociceptive in a number of animal models of chronic pain. However, an...

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Bibliographische Detailangaben
Hauptverfasser: Hama, Aldric T., Germano, Peter, Varghese, Matthew S., Cravatt, Benjamin F., Milne, G. Todd, Pearson, James P., Sagen, Jacqueline
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4008577/
https://ncbi.nlm.nih.gov/pubmed/24788435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096396
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