Epigenetic alteration by DNA-demethylating treatment restores apoptotic response to glucocorticoids in dexamethasone-resistant human malignant lymphoid cells

BACKGROUND: Glucocorticoids (GCs) are often included in the therapy of lymphoid malignancies because they kill several types of malignant lymphoid cells. GCs activate the glucocorticoid receptor (GR), to regulate a complex genetic network, culminating in apoptosis. Normal lymphoblasts and many lymph...

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Bibliografiske detaljer
Main Authors: Miller, Aaron L, Geng, Chuandong, Golovko, Georgiy, Sharma, Meenakshi, Schwartz, Jason R, Yan, Jiabin, Sowers, Lawrence, Widger, William R, Fofanov, Yuriy, Vedeckis, Wayne V, Thompson, E Brad
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Primary Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4008436/
https://ncbi.nlm.nih.gov/pubmed/24795534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-14-35
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