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A New, Lineage Specific, Autoup-Regulation Mechanism for Human Glucocorticoid Receptor Gene Expression in 697 Pre-B-Acute Lymphoblastic Leukemia Cells

Glucocorticoid (GC) steroid hormones induce apoptosis in acute lymphoblastic leukemia (ALL). Autoup-regulation of human GC receptor (hGR) levels is associated with sensitivity to GC-mediated apoptosis. Among the major hGR promoters expressed in 697 pre-B-ALL cells (1A, 1B, 1C, and 1D), only promoter...

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Bibliografiske detaljer
Main Authors: Geng, Chuan-dong, Vedeckis, Wayne V.
Format: Artigo
Sprog:Inglês
Udgivet: The Endocrine Society 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033051/
https://ncbi.nlm.nih.gov/pubmed/21084380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0249
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