The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts

PDK1 is a master kinase that activates at least six protein kinase groups including AKT, PKC and S6K and is a potential target in the treatment of a range of malignancies. Here we show overexpression of PDK1 in over 40% of myelomonocytic acute leukemia patients. Overexpression of PDK1 occurred unifo...

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Autori principali: Zabkiewicz, Joanna, Pearn, Lorna, Hills, Robert K., Morgan, Rhys G., Tonks, Alex, Burnett, Alan K., Darley, Richard L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2014
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4008098/
https://ncbi.nlm.nih.gov/pubmed/24334295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.096487
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