Direct Evidence of Conformational Changes Associated with Voltage Gating in a Voltage Sensor Protein by Time-Resolved X-ray/Neutron Interferometry

[Image: see text] The voltage sensor domain (VSD) of voltage-gated cation (e.g., Na(+), K(+)) channels central to neurological signal transmission can function as a distinct module. When linked to an otherwise voltage-insensitive, ion-selective membrane pore, the VSD imparts voltage sensitivity to t...

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Main Authors: Tronin, Andrey Y., Nordgren, C. Erik, Strzalka, Joseph W., Kuzmenko, Ivan, Worcester, David L., Lauter, Valeria, Freites, J. Alfredo, Tobias, Douglas J., Blasie, J. Kent
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007984/
https://ncbi.nlm.nih.gov/pubmed/24697545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/la500560w
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