Glutathione transferase-A2 S112T polymorphism predicts survival, transplant-related mortality, busulfan and bilirubin blood levels after allogeneic stem cell transplantation

Busulfan liver metabolism depends on glutathione, a crucial mediator of cellular and systemic stress. Here we investigated 40 polymorphisms at 27 loci involved in hepatic glutathione homeostasis, with the aim of testing their impact on the clinical outcome of 185 busulfan-conditioned allogeneic tran...

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Main Authors: Bonifazi, Francesca, Storci, Gianluca, Bandini, Giuseppe, Marasco, Elena, Dan, Elisa, Zani, Elena, Albani, Fiorenzo, Bertoni, Sara, Bontadini, Andrea, De Carolis, Sabrina, Sapienza, Maria Rosaria, Rizzi, Simonetta, Motta, Maria Rosa, Ferioli, Martina, Garagnani, Paolo, Cavo, Michele, Mantovani, Vilma, Bonafè, Massimiliano
Format: Artigo
Language:Inglês
Published: Ferrata Storti Foundation 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007922/
https://ncbi.nlm.nih.gov/pubmed/24056816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.089888
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