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Glutathione transferase-A2 S112T polymorphism predicts survival, transplant-related mortality, busulfan and bilirubin blood levels after allogeneic stem cell transplantation

Busulfan liver metabolism depends on glutathione, a crucial mediator of cellular and systemic stress. Here we investigated 40 polymorphisms at 27 loci involved in hepatic glutathione homeostasis, with the aim of testing their impact on the clinical outcome of 185 busulfan-conditioned allogeneic tran...

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Detalhes bibliográficos
Main Authors: Bonifazi, Francesca, Storci, Gianluca, Bandini, Giuseppe, Marasco, Elena, Dan, Elisa, Zani, Elena, Albani, Fiorenzo, Bertoni, Sara, Bontadini, Andrea, De Carolis, Sabrina, Sapienza, Maria Rosaria, Rizzi, Simonetta, Motta, Maria Rosa, Ferioli, Martina, Garagnani, Paolo, Cavo, Michele, Mantovani, Vilma, Bonafè, Massimiliano
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007922/
https://ncbi.nlm.nih.gov/pubmed/24056816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.089888
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