Structure−Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469

[Image: see text] The free fatty acid 1 receptor (FFA1 or GPR40), which is highly expressed on pancreatic β-cells and amplifies glucose-stimulated insulin secretion, has emerged as an attractive target for the treatment of type 2 diabetes. Several FFA1 agonists containing the para-substituted dihydr...

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Main Authors: Christiansen, Elisabeth, Due-Hansen, Maria E., Urban, Christian, Merten, Nicole, Pfleiderer, Michael, Karlsen, Kasper K., Rasmussen, Sanne S., Steensgaard, Mette, Hamacher, Alexandra, Schmidt, Johannes, Drewke, Christel, Petersen, Rasmus Koefoed, Kristiansen, Karsten, Ullrich, Susanne, Kostenis, Evi, Kassack, Matthias U., Ulven, Trond
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2010
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007913/
https://ncbi.nlm.nih.gov/pubmed/24900217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100106c
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