Discovery of a Potent Inhibitor of Anaplastic Lymphoma Kinase with in Vivo Antitumor Activity

[Image: see text] A series of novel 7-amino-1,3,4,5-tetrahydrobenzo[b]azepin-2-one derivatives within the diaminopyrimidine class of kinase inhibitors were identified that target anaplastic lymphoma kinase (ALK). These inhibitors are potent against ALK in an isolated enzyme assay and inhibit autopho...

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Detalhes bibliográficos
Main Authors: Ott, Gregory R., Tripathy, Rabindranath, Cheng, Mangeng, McHugh, Robert, Anzalone, Andrew V., Underiner, Ted L., Curry, Matthew A., Quail, Matthew R., Lu, Lihui, Wan, Weihua, Angeles, Thelma S., Albom, Mark S., Aimone, Lisa D., Ator, Mark A., Ruggeri, Bruce A., Dorsey, Bruce D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2010
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007912/
https://ncbi.nlm.nih.gov/pubmed/24900237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100158s
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