Discovery of a Potent Inhibitor of Anaplastic Lymphoma Kinase with in Vivo Antitumor Activity

[Image: see text] A series of novel 7-amino-1,3,4,5-tetrahydrobenzo[b]azepin-2-one derivatives within the diaminopyrimidine class of kinase inhibitors were identified that target anaplastic lymphoma kinase (ALK). These inhibitors are potent against ALK in an isolated enzyme assay and inhibit autopho...

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Autori principali: Ott, Gregory R., Tripathy, Rabindranath, Cheng, Mangeng, McHugh, Robert, Anzalone, Andrew V., Underiner, Ted L., Curry, Matthew A., Quail, Matthew R., Lu, Lihui, Wan, Weihua, Angeles, Thelma S., Albom, Mark S., Aimone, Lisa D., Ator, Mark A., Ruggeri, Bruce A., Dorsey, Bruce D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2010
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007912/
https://ncbi.nlm.nih.gov/pubmed/24900237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100158s
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