Vorinostat-Like Molecules as Structural, Stereochemical, and Pharmacological Tools

[Image: see text] The inhibitory activity of an ω-alkoxy analogue of the HDAC inhibitor, Vorinostat (SAHA), against the 11 isoforms of HDAC is described and evaluated with regard to structural biology information retrieved through computational methods. Preliminary absorption and metabolism studies...

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Bibliographic Details
Main Authors: Hanessian, Stephen, Auzzas, Luciana, Larsson, Andreas, Zhang, Jianbin, Giannini, Giuseppe, Gallo, Grazia, Ciacci, Andrea, Cabri, Walter
Format: Artigo
Language:Inglês
Published: American Chemical Society 2010
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007911/
https://ncbi.nlm.nih.gov/pubmed/24900179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100028g
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