Vorinostat-Like Molecules as Structural, Stereochemical, and Pharmacological Tools

[Image: see text] The inhibitory activity of an ω-alkoxy analogue of the HDAC inhibitor, Vorinostat (SAHA), against the 11 isoforms of HDAC is described and evaluated with regard to structural biology information retrieved through computational methods. Preliminary absorption and metabolism studies...

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Main Authors: Hanessian, Stephen, Auzzas, Luciana, Larsson, Andreas, Zhang, Jianbin, Giannini, Giuseppe, Gallo, Grazia, Ciacci, Andrea, Cabri, Walter
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2010
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007911/
https://ncbi.nlm.nih.gov/pubmed/24900179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100028g
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