Vorinostat-Like Molecules as Structural, Stereochemical, and Pharmacological Tools

[Image: see text] The inhibitory activity of an ω-alkoxy analogue of the HDAC inhibitor, Vorinostat (SAHA), against the 11 isoforms of HDAC is described and evaluated with regard to structural biology information retrieved through computational methods. Preliminary absorption and metabolism studies...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hanessian, Stephen, Auzzas, Luciana, Larsson, Andreas, Zhang, Jianbin, Giannini, Giuseppe, Gallo, Grazia, Ciacci, Andrea, Cabri, Walter
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2010
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007911/
https://ncbi.nlm.nih.gov/pubmed/24900179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100028g
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