HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor.

We have investigated the biological function of an unidentified human growth factor, the ligand of the putative HER2 receptor, by characterizing the signalling properties of its receptor. HER2 (or c-erbB-2), the human homolog of the rat neu proto-oncogene, encodes a transmembrane glycoprotein of the...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Lee, J, Dull, T J, Lax, I, Schlessinger, J, Ullrich, A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 1989
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC400786/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2565808/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1989.tb03361.x
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