HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor.

We have investigated the biological function of an unidentified human growth factor, the ligand of the putative HER2 receptor, by characterizing the signalling properties of its receptor. HER2 (or c-erbB-2), the human homolog of the rat neu proto-oncogene, encodes a transmembrane glycoprotein of the...

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Publié dans:	EMBO J
Auteurs principaux:	Lee, J, Dull, T J, Lax, I, Schlessinger, J, Ullrich, A
Format:	Artigo
Langue:	Inglês
Publié:	Nature Publishing Group 1989
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC400786/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2565808/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1989.tb03361.x
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