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Nanoscale Obstacle Arrays Frustrate Transport of EphA2 – Ephrin-A1 Clusters in Cancer Cell Lines

Juxtacrine signaling interactions between the EphA2 receptor tyrosine kinase and its ephrin-A1 ligand contribute to healthy tissue maintenance and misregulation of this system is observed in at least 40% of human breast cancer. Hybrid live cell – supported membrane experiments, in which membrane-lin...

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Main Authors: Lohmüller, Theobald, Xu, Qian, Groves, Jay T.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007685/
https://ncbi.nlm.nih.gov/pubmed/23668885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nl400874v
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