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Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity
DNA damage recognition subunits like DDB2 and XPC protect the human skin from ultraviolet (UV) light-induced genome instability and cancer, as demonstrated by the devastating inherited syndrome xeroderma pigmentosum. Here, we show that the beneficial DNA repair response triggered by these two genome...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4007632/ https://ncbi.nlm.nih.gov/pubmed/24770583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4695 |
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