SMAD4 Loss triggers the phenotypic changes of pancreatic ductal adenocarcinoma cells

BACKGROUND: SMAD4 is a gastrointestinal malignancy-specific tumor suppressor gene found mutated in one third of colorectal cancer specimens and half of pancreatic tumors. SMAD4 inactivation by allelic deletion or intragenic mutation mainly occurs in the late stage of human pancreatic ductal adenocar...

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Autori principali: Chen, Yu-Wen, Hsiao, Pi-Jung, Weng, Ching-Chieh, Kuo, Kung-Kai, Kuo, Tzu-Lei, Wu, Deng-Chyang, Hung, Wen-Chun, Cheng, Kuang-Hung
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007528/
https://ncbi.nlm.nih.gov/pubmed/24625091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-181
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