A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase

[Image: see text] In this study, we take advantage of the ability of HMG-CoA reductase (HMGR) from Pseudomonas mevalonii to remain active while in its crystallized form to study the changing interactions between the ligands and protein as the first reaction intermediate is created. HMG-CoA reductase...

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Main Authors: Steussy, C. Nicklaus, Critchelow, Chandra J., Schmidt, Tim, Min, Jung-Ki, Wrensford, Louise V., Burgner, John W., Rodwell, Victor W., Stauffacher, Cynthia V.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007485/
https://ncbi.nlm.nih.gov/pubmed/23802607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400335g
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