An atrial-fibrillation-linked connexin40 mutant is retained in the endoplasmic reticulum and impairs the function of atrial gap-junction channels

Connexin40 (Cx40)-containing gap-junction channels are expressed in the atrial myocardium and provide a low-resistance passage for rapid impulse propagation. A germline mutation in the GJA5 gene, which encodes Cx40, resulting in a truncated Cx40 (Q49X) was identified in a large Chinese family with l...

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Библиографические подробности
Главные авторы: Sun, Yiguo, Tong, Xiaoling, Chen, Honghong, Huang, Tao, Shao, Qing, Huang, Weixiong, Laird, Dale W., Bai, Donglin
Формат: Artigo
Язык:Inglês
Опубликовано: The Company of Biologists Limited 2014
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007407/
https://ncbi.nlm.nih.gov/pubmed/24626989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.013813
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