Atrial fibrillation-associated Connexin40 mutants make hemichannels and synergistically form gap junction channels with novel properties

Mutations of Cx40 (GJA5) have been identified in people with lone chronic atrial fibrillation including G38D and M163V which were found in the same patient. We used dual whole cell patch clamp procedures to examine the transjunctional voltage (V(j)) gating and channel conductance properties of these...

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Библиографические подробности
Главные авторы: Patel, Dakshesh, Gemel, Joanna, Xu, Qin, Simon, Adria R, Lin, Xianming, Matiukas, Arvydas, Beyer, Eric C, Veenstra, Richard D
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989446/
https://ncbi.nlm.nih.gov/pubmed/24457199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2014.01.010
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