Thymidylate synthetase mRNA levels are increased in liver metastases of colorectal cancer patients resistant to fluoropyrimidine-based chemotherapy

BACKGROUND: Fluoropyrimidines such as 5-fluorouracil (5-FU) and 5-fluoro-2'deoxyuridine (FUDR) are among the most effective chemotherapeutic agents for treatment of metastatic colorectal cancer (CRC). Increased expression of thymidylate synthetase (TS) in CRC metastases has been proposed to be...

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Detalhes bibliográficos
Main Authors: Libra, Massimo, Navolanic, Patrick M, Talamini, Renato, Cecchin, Erica, Sartor, Franca, Tumolo, Salvatore, Masier, Sara, Travali, Salvatore, Boiocchi, Mauro, Toffoli, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC400738/
https://ncbi.nlm.nih.gov/pubmed/15040806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-4-11
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