Recombinant adeno-associated virus-mediated human kallikrein gene therapy protects against hypertensive target organ injuries through inhibiting cell apoptosis

AIM: Overexpression of human tissue kallikrein (HK), mediated by recombinant adeno-associated virus (rAAV), decreased blood pressure in spontaneous hypertensive rats (SHRs) and reduced injury to the heart, aorta and kidney. In this study, we used both an in vivo animal model and in vitro cell cultur...

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Bibliografiska uppgifter
Huvudupphovsmän: Yan, Jiang-tao, Wang, Tao, Wang, Dao-wen
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2009
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Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007182/
https://ncbi.nlm.nih.gov/pubmed/19684610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2009.114
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