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Recombinant adeno-associated virus-mediated human kallikrein gene therapy protects against hypertensive target organ injuries through inhibiting cell apoptosis

AIM: Overexpression of human tissue kallikrein (HK), mediated by recombinant adeno-associated virus (rAAV), decreased blood pressure in spontaneous hypertensive rats (SHRs) and reduced injury to the heart, aorta and kidney. In this study, we used both an in vivo animal model and in vitro cell cultur...

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מידע ביבליוגרפי
Main Authors: Yan, Jiang-tao, Wang, Tao, Wang, Dao-wen
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007182/
https://ncbi.nlm.nih.gov/pubmed/19684610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2009.114
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